新型氧化玉米淀粉-聚己内酯基抗菌膜材料的制备及性能研究

Preparation and properties of oxidized corn starch-based nonionic antibacterial films

摘要:

通过简便的“一锅法”对氧化玉米淀粉（OCS）进行线性接枝吲哚乙酸单体（IAA），成功制得新型氧化玉米淀粉基抗菌材料（OI）。然后进一步将OI与具有生物降解性的聚己内酯（PCL）进行共混成膜，制得氧化玉米淀粉-聚己内酯基抗菌薄膜（PO）。通过FTIR、UV-vis、XRD等对所制备的OI以及PO的化学结构和性能特征进行了结构表征和性能测试。结果表明：IAA与OCS主要通过酯化反应进行结合，所制备的OI的取代度为60%。将OI与PCL复配后，所制备的PO结晶度明显下降。随着复合膜中OI的增加，所制备的膜材料透光率下降，抗拉强度增加，接触角略有下降。特别当OI用量为10%（以总质量为基准，下同）时，所制备的PO-10表现出良好的生物相容性、非浸出性和抗菌活性。根据圆盘扩散试验，所制备的抗菌材料最低抑菌浓度为0.5 g/L，远低于传统抗生素和大分子壳聚糖抗菌材料的用量。因此，所制备的PO不仅具有良好的功能特性，且原料绿色无毒、价廉易得，是一种潜在的生物医用材料。

Abstract:

A new oxidized corn starch-based antimicrobial material (OI) was successfully produced by linear grafting of indoleacetic acid monomer (IAA) on oxidized corn starch (OCS) through a simple "one-pot" method. OI was then further blended with biodegradable polycaprolactone (PCL) to produce oxidized corn starch-polycaprolactone based antimicrobial film (PO). The chemical structures and performance characteristics of the prepared OI and PO films were characterized by FTIR, UV-vis, and XRD. The results showed that IAA was combined with OCS mainly by esterification reaction, and the substitution degree reached 60%. After compounding OI with PCL, the crystallinity of the prepared PO films was significantly decreased. With the increase of OI content in the composite films, the prepared film materials decreased in light transmission, increased in tensile strength, and slightly decreased in contact angle. Especially, when the OI content was 10% (based on the total mass, the same below), the produced PO-10 showed good biocompatibility, non-leachability, and antibacterial activity. According to the disk diffusion test, the minimal inhibitory concentration of the produced antibacterial material was 0.5 g/L, which was much lower than the dosage of traditional antibiotics and macromolecular chitosan antibacterial materials. Therefore, the obtained PO not only has good functional properties, but also the raw material is green and non-toxic, inexpensive, and easy to obtain, which is a potential biomedical material.