葡萄糖响应型丙烯基氧化石墨烯微凝胶Pickering乳液的制备及性能

Preparation and properties of glucose-responsive GOM microgel Pickering emulsion

摘要:

提出以具有葡萄糖敏感的GOM/Poly(AAPBA-DMAA-co-AAm)微凝胶为Pickering 乳液中的乳化剂，为使用具有特定响应行为的功能性微凝胶提供了更广泛的应用。采用傅里叶红外光谱分析仪（FT-IR）、扫描电镜-X射线能谱（SEM-EDS）对微凝胶的形貌结构及元素组成进行表征。通过调控微凝胶中丙烯基氧化石墨烯（GOM）的含量和微凝胶在水相中的含量，制得了粒径分布均匀、分散性良好的具有葡萄糖敏感的O/W型稳定Pickering乳液。以胰岛素为模型负载药物，体外模拟释药表明：当葡萄糖的浓度为6 mM时，胰岛素的累积释放率可达到44.69%，当葡萄糖的浓度增加至40 mM时，胰岛素的累积释放率可达到94.21%。

Abstract:

GOM/Poly(AAPBA-DMAA-co-AAm) microgels with glucose-sensitive properties are proposed as emulsifiers in Pickering emulsions, providing a wider application for the use of functionalized microgels with specific response behaviors. The morphological structure and elemental composition of the microgels were characterized by Fourier infrared spectroscopy (FT-IR) and scanning electron microscopy-X-ray energy spectroscopy (SEM-EDS). By regulating the content of propylene-based graphene oxide (GOM) in microgels and the content of microgels in the aqueous phase, O/W-type stable Pickering emulsions with uniform particle size distribution and good dispersion were fabricated with glucose sensitivity. The in vitro simulated drug release using insulin as a model loaded drug showed that the cumulative release rate of insulin could reach 44.69% when the concentration of glucose was 6 mM and 94.21% when the concentration of glucose was increased to 40 mM.