改性HA纳米粒子在骨组织工程中的应用[ ]

The Application of Modified Hydroxyapatite Nanoparticles in Bone Tissue Engineering

摘要:

羟基磷灰石(HA)具有优异的生物活性和生物相容性,广泛应用于骨修复、再生和置换等骨组织工程,但HA纳米粒子难分散、强度低、高分子相融性差等缺点限制了其应用。为了克服这些缺点,研究员致力于探索改性或复合HA的方法,以改善其分散性、亲水性、抗菌性以及机械强度等,来满足临床应用的要求。本篇综述总结归纳了当前主流的HA纳米粒子改性方法,包括离子掺杂、表面改性、材料复合等。最后,我们还讨论了当前HA复合材料的研究热点,以期为HA复合材料相关基础研究提供有益的借鉴与启示。

Abstract:

Hydroxyapatite (HA) has excellent biological activity and biocompatibility, which widely used in bone repair, regeneration as well as replacement in bone tissue engineering. However, the intrinsic dispersibility, low mechanical properties, poor integration with polymer materials limit its application. In order to overcome their shortcomings, many researchers have explored the modify/composite methods of HA to improve the dispersion, hydrophilicity, antibacterial and mechanical strength for the clinical applications. This review introduces commonly modification methods of HA nanoparticles, such as ions doping, surface modification and material composite. Finally, we also discuss the current research hotspots so that provide more enlightenment and instructive effect on fundamental research of HA composite materials.