卟啉基金属有机框架在光疗领域的应用

Application of porphyrinoid-based metal-organic framework in the field of phototherapy

摘要:

卟啉基金属有机框架是金属或金属团簇与卟啉配体或其家族化合物配位自组装形成的晶体结构,结合了卟啉类分子良好的光物理特性和生物相容性,具有周期性和可调控的结构,在光化学领域和生物医药领域具有应用潜力；尤其是能够充分发挥卟啉类分子的优越性能,可通过光动、光热等光辅助治疗方法实现杀伤有害细胞的效果。本文综述了卟啉基金属有机框架近年的发展及其在生物医学领域包括抗肿瘤、抗菌方向上的研究现状,重点介绍了近几年卟啉基金属有机框架在光敏剂基础上的改进以及衍生出的多样化的功能,对其发展前景做出了展望。

Abstract:

Porphyrinoid-based metal organic framework (MOF) is featured with a crystal structure formed by the coordinating self-assembly between metal or metal clusters and porphyrin ligand or porphyrinoid family compounds. It combines the good photophysical properties and biocompatibility of porphyrinoid molecules, bearing a periodic and controllable structure, which can be potentially used in the field of photochemistry and biological medicine. In particular, the excellent performance of porphyrinoid molecules in the porphyrinoid MOFs can be remained which can thus play a role in killing harmful cells in human bodies via the photo-assisted medical treatment including photokinetic and photothermal therapies. In this paper, we reviewed the recent development of porphyrinoid-based MOFs and their applications in the biomedical field including anti-tumor and anti-bacterial treatments. We mainly focused on the performance improvement of porphyrinoid-based MOF type photosensitizers, compared to that of porphyrinoid molecules, and the diverse functions derived from the different type of porphyrinoid MOFs. The development potentials of porphyrinoid MOFs were also proposed.