导电自愈合可注射水凝胶对神经肌肉组织修复的研究进展

Research progress of conductive self-healing injectable hydrogels for neuromuscular tissue repair

摘要:

导电自愈合可注射水凝胶作为一种新型水凝胶材料，具有优异的柔韧性、延展性、自愈合性、可注射性和生物相容性以及导电性能，在生物医学领域展现出了巨大的应用潜力，已成为神经修复的重要功能材料。本文综述了导电自愈合可注射水凝胶在神经肌肉组织再生与修复领域的研究进展，系统梳理了聚合物导电自愈合可注射水凝胶、碳材料导电自愈合可注射水凝胶、离子导电自愈合可注射水凝胶等不同类型的导电材料的分类及其制备方法，深入探讨了该类水凝胶在神经肌肉组织再生与修复应用中面临的机遇与挑战。最后，对导电自愈合可注射水凝胶在神经肌肉组织修复领域的研究进行总结与展望，指出开发多功能神经修复水凝胶是未来的主要发展趋势。

Abstract:

Conductive self-healing injectable hydrogels, as a novel class of hydrogel materials, exhibit excellent flexibility, extensibility, self-healing properties, injectability, biocompatibility, and electrical conductivity. They have demonstrated significant application potential in the biomedical field and have emerged as crucial functional materials for nerve repair. This article reviews the research progress of conductive self-healing injectable hydrogels in the field of nerve regeneration and repair. It systematically categorizes and summarizes the preparation methods of various types of conductive materials, including polymer-based conductive self-healing injectable hydrogels, carbon nanomaterial-based conductive self-healing injectable hydrogels, and ion-conductive self-healing injectable hydrogels. Furthermore, it thoroughly explores the opportunities and challenges faced by these hydrogels in applications related to nerve regeneration and repair. Finally, the research on conductive self-healing injectable hydrogels in the field of nerve repair is summarized and prospected, and it is pointed out that developing multifunctional nerve repair hydrogels is the main future development trend.